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KMID : 0613820100200081207
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Journal of Life Science
2010 Volume.20 No. 8 p.1207 ~ p.1213
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Effect of Porcine Cancellous Bones on Regeneration in Rats with Calvarial Defect
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유경훈:Yoo Kyeong-Hoon
김세은:Kim Se-Eun/심경미:Shim Kyung-Mi/박현정:Park Hyun-Jung/최석화:Choi Seok-Hwa/강성수:Kang Seong-Soo
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Abstract
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The purpose of this study was to evaluate the effect of porcine cancellous bone as a scaffold in a rat calvarial defect model. Critical-sized defects were created in 30 male Sprague-Dawley rats. The animals were divided into critical defect (CD, n=10), β-tricalcium phosphate (TCP) graft (BT, n=10) and porcine cancellous bone graft (PCB, n=10) groups. Each defect was filled with β-TCP mixed with fibrin glue or porcine cancellous bone powder mixed with fibrin glue. In the CD group, the defect was left empty. All rats were sacrificed at 8 weeks after bone graft surgery, and bone formation was evaluated by gross observation, plain radiography, micro-computed tomography scanning and histological evaluation. Repair of bone defect was the least in the CD group, and significant new bone formation was observed in the PCB group. Grafting of porcine cancellous bone was more efficient for regenerating new bone than grafting β-TCP.
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KEYWORD
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Bone graft, porcine cancellous bone, β-TCP, calvarial defect, rat
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